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Physicians Longevity

Calcium AKG Rx (1,000 mg per 2 capsule serving, 60 capsules) by Physicians Longevity

SKU: PL591
Description

Support Energy Production, Bone Strength, and Metabolic Function With Age

  • Supports healthy aging processes
  • Supports heart, bone, and metabolic health
  • Supports cognitive vitality
  • Helps to boost antioxidant levels inside cells

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Supplement Facts
Supplement Facts
Serving Size: 2 Capsules
Servings Per Container: 30
Amount Per Serving %DV
Calcium Alpha Ketoglutarate 1,000 mg
† Daily Value not established
  • Other Ingredients: Organic Rice Flour, Vegetarian Capsule (Cellulose and water)
  • Contains No: Artificial colors, flavors, preservatives, dairy, eggs, fish, shellfish, tree nuts, peanuts, wheat, gluten, soybean, corn, or yeast.
  • Suggested Daily Use: Take 2 capsules daily, in the morning, with or without food.
  • Note: Store in a cool, dry place away from direct light. KEEP OUT OF REACH OF CHILDREN.
  • Caution: If you are pregnant, nursing, have a medical condition or are taking prescription drugs, consult your health care professional before using this product.

Alpha-ketoglutarate (AKG) is a compound that is created naturally in the body but tends to diminish with age. In supplement form, AKG can be attached to a calcium salt (Ca-AKG), which has been studied for its role in supporting metabolic function and longevity (1).

 

Ca-AKG is involved in stimulating protein synthesis and energy production in the body, as it is a vital component of the Kreb’s cycle - the process that creates ATP (energy) from food. Ca-AKG is also a source of the essential amino acids needed to make collagen, which is a protein that helps to support bone and muscle health.

 

Additionally, Ca-AKG facilitates our internal recycling process known as autophagy, which removes dysfunctional cells, cell parts, and proteins from the body. Autophagy tends to decrease with age, so Ca-AKG may be able to help support this process.

 

Research has found that AKG lengthened lifespan in roundworms by up to 50% and delayed signs of aging (2). This may be because Ca-AKG activates AMP-activated protein kinase (AMPK) - a pathway that senses and maintains cellular energy balance by supporting the function of our cells’ main energy hubs (the mitochondria) and healthy blood sugar control (3).

 

Ca-AKG has also been shown to boost cellular antioxidant levels in aged mice, which helped support the mice’s blood vessel elasticity - a measure of good cardiovascular health (4).

 

References: 

 

  1. Asadi Shahmirzadi A, Edgar D, Liao CY, et al. Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice. Cell Metab. 2020;32(3):447-456.e6. doi:10.1016/j.cmet.2020.08.004

  2. Chin R, Fu X, Pai M., et al. The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature. 2014;510:397–40. https://doi.org/10.1038/nature13264

  3. Wu N, Yang M, Gaur U, Xu H, Yao Y, Li D. Alpha-Ketoglutarate: Physiological Functions and Applications. Biomol Ther (Seoul). 2016;24(1):1-8. doi:10.4062/biomolther.2015.078

  4. Niemiec T, Sikorska J, Harrison A, et al. Alpha-ketoglutarate stabilizes redox homeostasis and improves arterial elasticity in aged mice. J Physiol Pharmacol. 2011;62(1):37-43.