Support Energy Production, Bone Strength, and Metabolic Function With Age
- Supports healthy aging processes
- Supports heart, bone, and metabolic health
- Supports cognitive vitality
- Helps to boost antioxidant levels inside cells
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Click HereCalcium AKG Longevity (1,000 mg per 2 capsule serving, 60 capsules)
SKU: PH591
Description
Supplement Facts
Rev.04.21
| Supplement Facts | ||
|---|---|---|
| Serving Size: 2 Capsules | ||
| Servings Per Container: 30 | ||
| Amount Per Serving | %DV | |
| Calcium Alpha Ketoglutarate | 1,000 mg | † |
| † Daily Value not established | ||
- Other Ingredients: Organic Rice Flour, Vegetarian Capsule (Cellulose and water)
- Does Not Contain: Artificial colors, flavors, preservatives, dairy, eggs, fish, shellfish, tree nuts, peanuts, wheat, gluten, soybean, corn, or yeast.
- Suggested Daily Use: Take 2 capsules daily, in the morning, with or without food.
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Storage: Store in a cool, dry place away from direct light.
- Caution: If you are pregnant, nursing, have a medical condition or are taking prescription drugs, consult your health care professional before using this product. KEEP OUT OF REACH OF CHILDREN.
Alpha-ketoglutarate (AKG) is a compound that is created naturally in the body but tends to diminish with age. In supplement form, AKG can be attached to a calcium salt (Ca-AKG), which has been studied for its role in supporting metabolic function and longevity (1).
Ca-AKG is involved in stimulating protein synthesis and energy production in the body, as it is a vital component of the Krebs cycle - the process that creates ATP (energy) from food. Ca-AKG is also a source of the essential amino acids needed to make collagen, which is a protein that helps to support bone and muscle health.
Additionally, Ca-AKG facilitates our internal recycling process known as autophagy, which removes dysfunctional cells, cell parts, and proteins from the body. Autophagy tends to decrease with age, so Ca-AKG may be able to help support this process.
Research has found that AKG lengthened lifespan in roundworms by up to 50% and delayed signs of aging (2). This may be because Ca-AKG activates AMP-activated protein kinase (AMPK) - a pathway that senses and maintains cellular energy balance by supporting the function of our cells’ main energy hubs (the mitochondria) and healthy blood sugar control (3).
Ca-AKG has also been shown to boost cellular antioxidant levels in aged mice, which helped support the mice’s blood vessel elasticity - a measure of good cardiovascular health (4)
References:
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Asadi Shahmirzadi A, Edgar D, Liao CY, et al. Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice. Cell Metab. 2020;32(3):447-456.e6. doi:10.1016/j.cmet.2020.08.004
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Chin R, Fu X, Pai M., et al. The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature. 2014;510:397–40. https://doi.org/10.1038/nature13264
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Wu N, Yang M, Gaur U, Xu H, Yao Y, Li D. Alpha-Ketoglutarate: Physiological Functions and Applications. Biomol Ther (Seoul). 2016;24(1):1-8. doi:10.4062/biomolther.2015.078
- Niemiec T, Sikorska J, Harrison A, et al. Alpha-ketoglutarate stabilizes redox homeostasis and improves arterial elasticity in aged mice. J Physiol Pharmacol. 2011;62(1):37-43..