Nicotinamide Riboside Pro Complete (500 mg NIAGEN®, 500 mg Trans-Resve

Supplement Facts
Serving Size: 2 Capsules
Servings Per Container: 30
Amount Per Serving	%DV
Nicotinamide Riboside Chloride (NIAGEN®)	500 mg	†
Micronized Trans Resveratrol (from Japanese Knotweed root)	500 mg	†
TMG (Trimethylglycine)	250 mg	†
† Daily Value not established.

Benefits +

NAD+ precursor that supports cellular function, heart health and cognition

Nicotinamide riboside (NR) is a derivative of the B-vitamin niacin that supports health and longevity by serving as a precursor to NAD+.
NR supplementation has been found to improve various parameters of health, including cardiovascular health, cognition and neurological function, gene expression and healthy body weight.
NR Pro Complete is the first and only perfectly balanced combination of NR, Trans-Resveratrol and TMG on the market. Instead of having to take three separate supplements each day, you can now get the ideal balance of all three in one convenient serving.

Supports Cognition. Declining cognitive function with age is related to reduced NAD+ levels that impair mitochondrial function. Replenishing NAD+ stores through NR may be able to prevent this dysfunction. One study found that adults with a newly diagnosed neurodegenerative condition who took 1,000 mg NR for 30 days had increased cerebral NAD+ levels, mild clinical improvement and reduced activity of pro-inflammatory molecules in the cerebrospinal fluid. NR also increased the activity of genes involved with mitochondrial function and antioxidant responses. In animal and cell-based models, NR boosted brain NAD+ levels in mice, supported cognitive performance and behavior and slowed disease progression in several others. The mechanisms behind these benefits included reduced neuroinflammation, increased levels of BDNF (brain-derived neurotrophic factor) and elevated sirtuin activity. (1,2)

Supports Heart Health. Boosting NAD+ bioavailability with precursors like NR has been proposed as a strategy for supporting cardiovascular health in aging adults. Research showed that adults who took 1,000 mg of NR per day for six weeks had reduced blood pressure. Specifically, people with elevated blood pressure had a reduction in average systolic blood pressure (SBP) after taking NR compared to the placebo. NR had positive effects on risk factors for age-related cardiovascular events, such as aortic stiffness. (3)

Supports Metabolism and Healthy Weight. Although excessive body weight can develop at any age, adults over age 40 are particularly susceptible to age-related weight gain as metabolism slows down and body composition is altered to favor fat over lean muscle. As obese individuals have reductions in both NAD+ levels and ATP (energy) production, replenishing NAD+ through NR can help to reverse this while improving metabolic pathways to maintain a healthy weight. Research shows that supplementing with NR reduces fat mass and increases fat-free mass. (4)

References:

1. Brakedal B, Dölle C, Riemer F, et al. The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson's disease. Cell Metab. 2022;34(3):396-407.e6. doi:10.1016/j.cmet.2022.02.001

2. Nkrumah-Elie Y, Erickson A, Idoine R, et al. Nicotinamide Riboside Supports Brain Health: Assessing the Evidence. Curr Dev Nutr. 2022;6(Suppl 1):798. Published 2022 Jun 14. doi:10.1093/cdn/nzac064.017

3. Martens CR, Denman BA, Mazzo MR, et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun. 2018;9(1):1286. Published 2018 Mar 29. doi:10.1038/s41467-018-03421-7

4. Remie CME, Roumans KHM, Moonen MPB, et al. Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans. Am J Clin Nutr. 2020;112(2):413-426. doi:10.1093/ajcn/nqaa072

How it Works +

Nicotinamide riboside (NR) is a derivative of the B-vitamin niacin that can improve health and longevity by serving as a precursor to NAD+.
ProHealth Longevity’s NR Pro Complete is a trio of longevity-supporting compounds, including NR, trans-resveratrol and TMG.
This formula also contains 250 mg of TMG (Trimethylglycine), an amino acid that supports the body's methylation processes and 500 mg of micronized trans-resveratrol.
NR supplementation has been found to improve various parameters of health, including cardiovascular health, cognition and neurological function, gene expression and healthy body weight.
NR and trans-resveratrol work together, which is why longevity experts recommend taking them together for the greatest effectiveness. This dynamic duo has been likened to the operation of a car, with NR as the fuel and trans-resveratrol as the accelerator pedal.
ProHealth’s Nicotinamide Riboside Pro 300 utilizes a patented, clinically-researched form of NR called Niagen®.
TMG, also known as betaine, is an amino acid that supports the body's methylation processes. These processes are known to decline with age and may also be affected by common gene variations. Also, NR supplementation may require the use of methyl groups to help facilitate the conversion of NAD+ in your cells.
Many top anti-aging experts suggest that safeguarding against methyl depletion may be a wise proactive step to augment your NR intake. TMG, the choice of many of those experts, is an excellent way to help support your body's ability to maintain an adequate methyl pool.

How Ours is Better +

Clinically-Proven NR. ProHealth Longevity’s NR uses a clinically-proven form of NR (Niagen®) to boost NAD+ levels.
Unique Trio of Longevity-Supporting Ingredients at High Doses. NR Pro Complete is the first and only perfectly balanced combination of NR, Trans-Resveratrol and TMG on the market. Instead of having to take three separate supplements each day, you can now get the ideal balance of all three in one convenient serving. A single scoop of NR Pro Complete will provide you with 500 mg of NR, 500 mg of trans-resveratrol and 200 mg of TMG – the daily dosage most often recommended by the world's leading longevity experts.
Combines NR and TMG. When taken as a supplement, NAD+ boosters like NR may require the use of methyl groups to help facilitate the conversion of NAD+ in your cells. Although there is currently no evidence suggesting that NR’s natural methylation process depletes the methyl pool, many top anti-aging experts suggest that safeguarding against methyl depletion may be a wise proactive step to augment your NR intake. TMG, the choice of many of those experts, is an excellent way to help support your body's ability to maintain an adequate methyl pool.
Bioavailable Form of Resveratrol. Regular resveratrol is composed of 50% trans-resveratrol and 50% cis-resveratrol. Because research suggests that only the trans-form has valuable biological activity, NR Pro Complete contains pure, natural, pharmaceutical-grade trans-resveratrol that is micronized for ease of absorption.
Convenient Capsule Form. This NR comes in capsule form, making it easy and convenient to take NR while on the go or traveling.
Solvent-Free. Compared to other NR products, ours is made without any chemical solvents.
Quality Manufacturing Practices. All of our products are manufactured in an FDA-registered, GMP-certified facility.
Third-Party Tested in the USA. Every batch is third-party tested in US laboratories to ensure the highest quality, purity and potency. Certificates of Analysis are available.

Nicotinamide Riboside Pro Complete (500 mg NIAGEN®, 500 mg Trans-Resveratrol, 250 mg TMG per 2-capsule serving, 60 capsules)

NAD+ precursor that supports cellular function, heart health and cognition

NAD+ precursor that supports cellular function, heart health and cognition

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