A Methyl Donor That Complements NMN Supplementation
- Supports cardiovascular health*
- Promotes healthy homocysteine levels*
- Helps replenish the body's methyl pool*
To place an order or view product pricingClick Here
|Serving Size: 1 Tablet
|Servings Per Container: 120|
|Amount Per Serving||%DV|
|Trimethylglycine (TMG) (Betaine Anhydrous)||1 g (1,000 mg)||†|
|† Daily Value not established|
Trimethylglycine (TMG), also known as betaine anhydrous, is an amino acid that supports the body's methylation processes. Methylation is a fundamental biochemical process in which one carbon atom and three hydrogen atoms (CH3) are transferred from one molecule to another. This process is responsible for numerous important bodily functions, such as:
Our bodies contain a “methyl pool” of CH3 that is available whenever needed. As long as we have enough methyl groups stored in the pool, methylation typically is not a problem. However, there are a couple of things that may contribute to the depletion of the body's methyl pool.
MTHFR Variants - Methylenetetrahydrofolate reductase (MTHFR) is a gene with common mutations that can interfere with the methylation process, causing high levels of homocysteine (a known risk factor in heart disease) in the blood and low folate levels. Up to 40% of the population may have one or both genetic mutations.
Aging and Epigenetics - Methylation of DNA plays a crucial role in epigenetics, switching different sequences of genetic material on and off as needed. The body's methylation ability and subsequent DNA expression is known to decline with age. Anti-aging researchers think these changes in DNA expression may be a contributing factor to many age-related diseases.*
NMN Supplementation and Methylation Support
When taken as a supplement, NMN may require the use of methyl groups to help facilitate the conversion of NAD+ in cells, thereby activating sirtuin genes and promoting longevity. Although there is currently no evidence suggesting NMN’s natural methylation process depletes the methyl pool, many top anti-aging experts suggest that safeguarding against methyl depletion may be a wise proactive step to augment NMN intake. TMG, the choice of many of those experts, is an excellent way to help support the body's ability to maintain an adequate methyl pool.